HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 44963Generated: October 25, 2026
Dimethylformamide → 4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/44963
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Bromopyrazole | HCID 16375 | — |
| Reactant | 4-Bromo-1H-pyrrolo[2,3-b]pyridine | HCID 22273643 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine | HCID 57477672 | — |
Reaction Steps
A mixture of 4-bromo-1H-pyrrolo[2,3-b]pyridine (1.10 g, 0.00558 mol) and 4-bromo-1H-pyrazole (1.2 g, 0.0084 mol) was heated neat to 150° C. for 2 h. DMF was added to dissolve the crude residue. This residue was taken up in EtOAc and washed with 1N NaOH. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to give a crude 4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine residue, LC/MS (M+H)+: 263,265.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08541425B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-1de1844c622f487f92865c434c36fd30 |
|---|
| Source note | uspto-grants-2013_09 |
|---|
