Hydrochloric Acid → HCID 56656336, compound

Participants

Reaction Steps

To a solution of (S)-6-tert-butyl-2-(3-(5-(5-(2,2-dimethyl-1,3-dioxolan-4-yl)pyrazin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one (99 mg, 0.16 mmol) in tetrahydrofuran (4 mL) was added hydrochloric acid (1.0 N, 4 mL) and the resulting mixture stirred at room temperature overnight. The reaction mixture was poured into a saturated ammonium chloride solution and extracted with dichloromethane (2×50 mL). The combined organic layers were dried over magnesium sulfate. The mixture was filtered and evaporated and the residue recrystallized from dichloromethane and isopropyl acetate to give 6-tert-butyl-2-(3-{5-[5-((S)-1,2-dihydroxy-ethyl)-pyrazin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one (15.4 mg, 17%) as an off white solid: Mp. 218-224° C.; 1H NMR (300 MHz, DMSO-d6) δ ppm 1.37 (s, 10H) 3.44-3.95 (m, 5H) 4.32-4.82 (m, 4H) 5.40 (d, J=4.91 Hz, 1H) 7.22-7.99 (m, 5H) 8.16-8.65 (m, 3H) 8.78 (s, 1H) 9.81 (s, 1H).

Provenance & Evidence