4-Methyl-1-(6-nitropyridin-3-yl)piperidin-4-ol → 1-(6-Aminopyridin-3-yl)-4-methylpiperidin-4-ol

Participants

Reaction Steps

A solution of 4-methyl-1-(6-nitropyridin-3-yl)piperidin-4-ol (807 mg, 3.67 mmol) in methanol (15 ml) was hydrogenated at 50 psi with 10% Pd/C (117 mg, 110 umol) overnight. The catalyst was filtered off and the resultant filtrate was concentrated in vacuo to afford 1-(6-aminopyridin-3-yl)-4-methylpiperidin-4-ol. The product was carried to next reaction without further purification.

Provenance & Evidence