Tetrahydrofuran → 3-[(4-Methylamino-3-nitro-benzoyl)-phenyl-amino]propionic acid methyl ester

Participants

Reaction Steps

To a solution of 4-methylamino-3-nitro-benzoic acid chloride (23.3 mmol) and 3-phenylamino-propionic acid methyl ester (23.3 mmol) in 80 mL dry tetrahydrofuran (THF) triethylamine (50.2 mmol) was added dropwise under stirring at room temperature. After three hours the reaction mixture was evaporated to dryness, the remaining solid triturated with water and the solid product isolated through filtration.

Provenance & Evidence