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HRID449742

反应详情

EQUATION

反应方程式

HRID 449742 的结构方程式

REACTANTS

反应物

1
结构：CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1NC(=O)CNc1ccc(C#N)cc1
HCID66706328

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C)c1ccccc1
HCID58069422

未命名化合物

收率 58%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A solution of the product of 1c (22.6 mmol) in 100 mL concentrated acetic acid was heated to reflux for one hour. The solution was then evaporated to dryness, the remaining solid triturated with water and under stirring the pH was adjusted to about 8-9. The crude product was isolated through extraction with ethyl acetate and purified by chromatography on silica gel (eluent: dichloromethane/ethanol 1:1).

WORKUP

后处理

  1. temperatureto reflux for one hour
  2. customThe solution was then evaporated to dryness
  3. customthe remaining solid triturated with water