Tetrahydrofuran → HCID 67993137, compound

Participants

Reaction Steps

10% Pd/C (0.035 g) was added in one portion to a stirred solution of (S)-6-(4-benzyloxycarbonylamino-benzoylamino)-2-carbazol-9-yl-hexanoic acid methyl ester 11 (0.350 g, 0.62 mmol) in a 1:1 mixture of THF (5 mL) and isopropanol (5 mL) and nitrogen atmosphere. The reaction mixture was subsequently stiffed under hydrogen atmosphere for 4 h at room temperature. The reaction mixture was passed through a celite pad, and the filtrate was concentrated in under reduced pressure to give (S) 6-(4-amino-benzoylamino)-2-carbazol-9-yl-hexanoic acid methyl ester (12) (0.260 g, 98%) as a white solid.

Provenance & Evidence