Isopropanol → HCID 58554732, compound

Participants

Reaction Steps

10% Palladium on charcoal (0.040 g) was added in one portion to a stirred solution of 18 (0.360 g, 0.57 mmol) in a 1:1 mixture of isopropanol (4 mL) and THF (4 mL) under nitrogen atmosphere. The suspension was then stirred under hydrogen atmosphere for 6 h. The solution was filtered through celite and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography CH3OH:CH2Cl2 (5:95) to afford to obtain (S)-4-(2-(4-aminobenzoyloxy)ethoxy)-2-(9H-carbazol-9-yl)-4-oxobutanoic acid 19 (0.230 g, 96%) as a white solid.

Provenance & Evidence