1,1'-Carbonyldiimidazole → HCID 136372361, compound

Participants

Reaction Steps

2-(3-Chlorophenyl)-2-((3,4-dimethylphenyl)thio)acetic acid (3.00 g, 9.78 mmol) was dissolved in dichloroethane, then carbonyldiimidazole (2.00 g, 12.35 mmol) was added, the resulting reaction mixture was stirred for 10 minutes, N′,4-dihydroxy-3,5-dimethylbenzimidamide crude (prepared according to Diana, Guy D et al. Journal of Medicinal Chemistry, 1994, vol. 37 (15) p. 2421-2436) (1.80 g, 9.99 mmol) was added. The reaction mixture was stirred for 30 minutes, then concentrated. Flash chromatography (40% EtOAc/Hex) gave the desired adduct which was dissolved in xylene (10 mL) and heated to 125° C. for 30 minutes, then cooled. Flash chromatography (20% EtAc/Hex) gave Intermediate 4.

Provenance & Evidence