反应详情

At 20° C., 30 ml of thionyl chloride are initially charged and 3 g of 3,5-dichloro-2-amino-N-(2-hydroxyethoxy)benzamide are added in 3 portions with stirring. The mixture is stirred at 70° C. for 12 h. The reaction mixture is then cooled and carefully poured onto ice-water. The mixture is extracted twice with in each case 150 ml of dichloromethane and the extracts are dried with sodium sulphate and evaporated to dryness using a rotary evaporator.

1. stirringThe mixture is stirred at 70° C. for 12 h
2. temperatureThe reaction mixture is then cooled
3. additioncarefully poured onto ice-water
4. extractionThe mixture is extracted twice with in each case 150 ml of dichloromethane
5. dry with materialthe extracts are dried with sodium sulphate
6. customevaporated to dryness
7. customa rotary evaporator