HCID 178424719, compound → HCID 178424718, compound

HRID 449796Notes

Reaction equation

HRID 449796 reaction equation
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([C:8]2[NH:13][CH2:12][CH2:11][O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1>C(O)C.[Pd]>[O:10]1[CH2:11][CH2:12][NH:13][C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=2[NH2:14])=[N:9]1

Participants

4

Reactant 1

HCID 178424719HCID 178424719, compound

Product 1

HCID 178424718HCID 178424718, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
21 °C

Procedure

3 g (13.6 mmol) of 3-(3-methyl-2-nitrophenyl)-5,6-dihydro-4H-[1,2,4]oxadiazine are dissolved in 40 ml of ethanol, and 0.3 g of Pd/C (5%) is added. The mixture is then stirred at 21° C. under a hydrogen pressure of 3 bar for 72 h. The reaction mixture is then filtered and the ethanol is distilled off under reduced pressure.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. distillationthe ethanol is distilled off under reduced pressure

Sources & evidence

ORD record
ord-f43cc5333c354767ad47a51f513ba356
Source dataset
uspto-grants-2013_07
Patent number
US08486934B2

Reaction notes

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