Chloroacetic Acid → HCID 178439470, compound

Participants

Reaction Steps

Chloroacetic acid (22 g, 0.23 mol) and 6-isopropyl-2-mercaptopyrimidin-4-ol (10 g, 59 mmol) were suspended in water (150 mL). The reaction mixture was refluxed for 6 hours. Concentrated HCl (0.36 mL) was added carefully, and the reaction was returned to reflux for 12 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give 6-isopropylpyrimidine-2,4-diol (9.0 g, yield: 100%), which was used in the next step without further purification. LCMS (ESI) m/z: 155.0 [M+H+].

Provenance & Evidence