Benzoyl chloride → HCID 86648967, compound

Participants

Reaction Steps

To a solution of (3-hydroxycyclobutyl)carbamic acid tent-butyl ester (180 mg, 0.96 mmol) in pyridine (4 mL) was added benzoyl chloride (116 μL, 1.0 mmol). The reaction mixture was stirred at room temperature for 2 hrs and then concentrated under reduced pressure. The residue was dissolved in EtOAc (20 mL), washed with 1 N HCl, water and brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (Et2O/pentane: gradient 0% to 50%) to give benzoic acid 3-tert-butoxycarbonylaminocyclobutyl ester as a white solid (262 mg, yield: 94%). LCMS (ESI) m/z: 192 [M+H-BOC]+

Provenance & Evidence