Thionyl Chloride → 2-Chloronicotinoyl chloride

Participants

Reaction Steps

2-Chloro nicotinic acid (5 g, 31.8 mmol) was heated to reflux with redistilled thionyl chloride (5.6 g, 47 mmol) for 8 hr, resulting in a clear solution. The reaction mixture was concentrated to dryness and the traces of thionyl chloride co-distilled with toluene (15 ml) to give 2-chloro-nicotinoyl chloride (5.2 g, 94%) as oil.

Provenance & Evidence