HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 2-Phenylindolizine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-methyl-1-(2-oxo-2-phenylethyl)pyridinium bromide | HCID 12316824 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Phenylindolizine | HCID 96128 | 70% |
Reaction Steps
A solution of sodium hydrogen carbonate (10.5 g, 119.8 mmol) in water (125 ml) was added to 2-methyl-1-(2-oxo-2-phenyl-ethyl)-pyridinium bromide (35.0 g, 119.8 mmol) and the reaction heated to reflux for 30 min. The resultant solid was filtered, washed with water and then dried under vacuum to yield 2-phenyl-indolizine (16.0 g, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486962B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-e0d62e0532ef4a87b0dfe39f58daa357 |
| Source note | uspto-grants-2013_07 |