反应详情

A mixture of 1-chloro-4-nitro benzene (1.5 g, 9.5 mmol) and thiomorpholine (1.0 g, 9.7 mmol) was refluxed in n-butanol overnight. The solvent was evaporated under reduced pressure to give a residue, which on triturating with water gave a precipitate. The solid was filtered and washed thoroughly with water, followed by a small amount of pet ether to yield crude solid. Recrystallisation with ethanol yielded 4-(4-nitro-phenyl)-thiomorpholine (1.5 g, 71%).

1. customThe solvent was evaporated under reduced pressure
2. customto give a residue, which
3. customon triturating with water
4. customgave a precipitate
5. filtrationThe solid was filtered
6. washwashed thoroughly with water
7. customto yield crude solid
8. customRecrystallisation with ethanol