反应详情

To mixture of p-nitrophenylacetic acid (1 g, 5.5 mmol) in benzene (10 ml) was added thionyl chloride (0.8 ml) at room temperature. The reaction mixture was heated to reflux for 12 hr and then cooled. The excess thionyl chloride and benzene were removed in vacuo to obtain (4-nitro-phenyl)-acetyl chloride (1 g, 91%).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 12 hr
3. temperaturecooled
4. customThe excess thionyl chloride and benzene were removed in vacuo