1-(2-Methoxy-5-nitrophenyl)ethanone → 1-(5-Amino-2-methoxyphenyl)ethanone

Participants

Reaction Steps

A solution of 1-(2-methoxy-5-nitro-phenyl)-ethanone (350 mg, 1.8 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (70 mg) at atmospheric pressure until no further absorption of gas took place. The reaction mixture was then filtered over celite and the filtrate concentrated under reduced pressure to give 1-(5-amino-2-methoxy-phenyl)-ethanone (250 mg, 85%) as a solid.

Provenance & Evidence