反应详情

温度

62.5 °C

2-Chloro-5-nitro benzoic acid (2 g, 10 mmol) was added to 40% dimethylamine aq. solution (20 ml) at room temperature and then heated at 60-65° C. for 3 hr. The reaction mixture was chilled to 0° C. and acidified with dilute acetic acid. The mixture was then extracted with ethyl acetate, and the organic layer washed with water, then brine and dried. Evaporation of the solvent yielded 2-dimethylamino-5-nitro-benzoic acid (2.1 g, 91%), as a solid.

1. temperatureThe reaction mixture was chilled to 0° C.
2. extractionThe mixture was then extracted with ethyl acetate
3. washthe organic layer washed with water
4. dry with materialbrine and dried
5. customEvaporation of the solvent