反应详情

温度

0 °C

1,4-Dioxaspiro[4.5]decan-8-ol (0.40 g, 0.0025 mol) was dissolved in chloroform (10.0 mL) and the resulting mixture was cooled at 0° C. To the mixture was added TEA (0.49 mL, 0.0035 mol) and methanesulfonyl chloride (0.23 mL, 0.0030 mol) and this mixture was stirred at 0° C. for 2 hours. The reaction was extracted with ethyl acetate and the organic extracts were washed with water, and saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification.

1. extractionThe reaction was extracted with ethyl acetate
2. washthe organic extracts were washed with water, and saturated NaCl
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. customThe crude product was used in the next reaction without further purification