反应详情

To a solution of sodium methoxide (0.090 g of sodium) in MeOH (12 mL) was added 0.486 g (3.03 mmol) of 2-chloro-5-nitropyrimidine, and the mixture was heated under reflux for 1 hr. After cooling, the mixture was concentrated in vacuo, extracted with EtOAc, and washed with water. The aqueous layer was extracted with CHCl3 and the combined organic layers were dried (Na2SO4), and concentrated, to give 0.347 g (75% yield) of 2-methoxy-5-nitropyrimidine as a yellow powder: 1H NMR (CDCl3) δ9.31 (s, 2H), 4.17 (s, 3H); LCMS (APCI+) m/z: 156 (MH+, 100%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hr
3. temperatureAfter cooling
4. concentrationthe mixture was concentrated in vacuo
5. extractionextracted with EtOAc
6. washwashed with water
7. extractionThe aqueous layer was extracted with CHCl3
8. dry with materialthe combined organic layers were dried (Na2SO4)
9. concentrationconcentrated