Hydrochloric Acid → HCID 178510130, compound

Participants

Reaction Steps

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-{2,6-dichloro-5-fluoro-3-[(tert.butoxycarbonylamino)-methyl]-phenylamino}-5-[4-fluoro-piperidinyl]-3H-imidazo[4,5-b]pyridine-6-carboxamide (180 mg, 0.250 mmol), 4N HCl in dioxane (5.0 mL) and dioxane (10 mL) is stirred overnight, concentrated, dissolved in water, filtered, basicified with aq NH3-solution and extracted with DCM. The organic phase is dried with MgSO4, filtered and concentrated.

Provenance & Evidence