HCID 67957578, compound → HCID 67957760, compound

HRID 450343Notes

Reaction equation

HRID 450343 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH:14][CH3:15])=[N:7][C:6]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([F:25])([F:24])[F:23])[CH2:18][CH2:17]1)[CH3:2]>[Pd].CCO>[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH:14][CH3:15])=[N:7][C:6]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([F:24])([F:25])[F:23])[CH2:18][CH2:17]1)[CH3:2]

Participants

4

Reactant 1

HCID 67957578HCID 67957578, compound

Product 1

HCID 67957760HCID 67957760, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid ethylester (6.0 g, 15.9 mmol), Pd/C (800 mg) and EtOH (100 mL) is stirred under 60 psi H2-atmosphere for 6 h. The mixture is filtered, and the filtrate is concentrated. HPLC Rt=1.13 min (method A). MS m/z: 347 [M+H]+.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-661d5872f84546dbbded1510bac97c6d
Source dataset
uspto-grants-2013_07
Patent number
US08486968B2

Reaction notes

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