Triethylamine → HCID 178458609, Verbindung

HRID 450358Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450358
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[N:3]=1.[CH:12]([O:15][C:16]1[NH:20][N:19]=[C:18]([NH2:21])[CH:17]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:11][C:4]1[N:3]=[C:2]([NH:21][C:18]2[CH:17]=[C:16]([O:15][CH:12]([CH3:14])[CH3:13])[NH:20][N:19]=2)[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 852392,6-Dichloro-3-nitropyridineHCID 1784587215-Isopropoxy-1H-pyrazol-3-amine2×

Produkt 1

HCID 178458609HCID 178458609, VerbindungAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 2,6-dichloro-3-nitropyridine (0.5 g) and 5-isopropoxy-1H-pyrazol-3-amine (Intermediate 6, 0.35 g) in acetonitrile (10 mL) with triethylamine (2 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (Hexane/Ethyl acetate) to afford 0.45 g desired product. MS (electrospray): 298 (M+1) for C11H12ClN5O3.

Aufarbeitung

  1. concentrationThe resulting mixture was concentrated
  2. customthe resulting residue was separated by silica gel column (Hexane/Ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-a0aae902817c4d5da4a907ee2478f91a
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486966B2

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