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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 450385Generated: October 25, 2026

1H-Pyrazol-3-amine, 5-methyl- → 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amine

https://huagongshe.com/reaction/450385

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Pyrazol-3-amine, 5-methyl-HCID 93146—
Reactant2,6-Dichloro-3-nitropyrimidineHCID 18469972—
ReactantHCID 178458615HCID 178458615—
Product2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amineHCID 71538938—

Reaction Steps

The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 30 using 2,6-dichloro-3-nitropyrimidine and 5-methyl-1H-pyrazol-3-amine as the starting materials. LCMS: 255 [M+1].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08486966B2
Source datasetuspto-grants-2013_07
ORD IDord-a8393a7fb5724537bad711b9243a0667
Source noteuspto-grants-2013_07