1H-Pyrazol-3-amine, 5-methyl- → Ethyl 2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate

HRID 450386Notes

Reaction equation

HRID 450386 reaction equation
ClC1N=C(NC2C=C(OC(C)C)NN=2)C([N+]([O-])=O)=CN=1.[Cl:21][C:22]1[N:27]=[C:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:25]([N+:33]([O-:35])=[O:34])=[C:24](Cl)[N:23]=1.[CH3:37][C:38]1[NH:42][N:41]=[C:40]([NH2:43])[CH:39]=1>>[Cl:21][C:22]1[N:27]=[C:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:25]([N+:33]([O-:35])=[O:34])=[C:24]([NH:43][C:40]2[CH:39]=[C:38]([CH3:37])[NH:42][N:41]=2)[N:23]=1

Participants

4

Reactant 3

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 2761044Ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylateHCID 178458615HCID 178458615, compound

Product 1

HCID 57757807Ethyl 2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate

Procedure

The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 30 using ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate and 5-methyl-1H-pyrazol-3-amine as the starting materials. LCMS: 327 [M+1].

Sources & evidence

ORD record
ord-436a7518d856442d95fa0b7055d4e931
Source dataset
uspto-grants-2013_07
Patent number
US08486966B2

Reaction notes

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