HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate → Ethyl 2-{[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate | HCID 57757807 | — |
| Reactant | (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride | HCID 66624037 | — |
| Product | Ethyl 2-{[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate | HCID 68781144 | — |
Reaction Steps
The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 18 using [(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]amine hydrochloride (Intermediate 15) and ethyl 2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-5-nitropyrimidine-4-carboxylate (Intermediate 48) as the starting materials. LCMS: 432 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486966B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-9af269a995a345f3ab22897e33f2fef9 |
| Source note | uspto-grants-2013_07 |