1H-Pyrazol-3-amine, 5-methyl- → 2-Chloro-6-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amine

HRID 450391Notes

Reaction equation

HRID 450391 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4](Cl)[N:3]=1.[CH3:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1.[CH3:20][O-:21].[Na+]>>[Cl:1][C:2]1[N:7]=[C:6]([NH:19][C:16]2[CH:15]=[C:14]([CH3:13])[NH:18][N:17]=2)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([O:21][CH3:20])[N:3]=1

Participants

4

Reactant 3

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 42978432,4,6-Trichloro-5-nitropyrimidine2×HCID 10942334Sodium Methoxide

Product 1

HCID 866492852-Chloro-6-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amine

Procedure

The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 18 using 2,4,6-trichloro-5-nitropyrimidine (Intermediate 37), 5-methyl-1H-pyrazol-3-amine and sodium methoxide as the starting materials. LCMS: 285 [M+1].

Sources & evidence

ORD record
ord-142abff36d424c32981f1d185e0f9f1c
Source dataset
uspto-grants-2013_07
Patent number
US08486966B2

Reaction notes

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