Ammonium Hydroxide → HCID 178452801, compound

Participants

Reaction Steps

A solution of NaOAc (0.6 g, 7.4 mmol) in water (1.5 mL) was treated with 3,3-dibromo-1,1,1-trifluoro-propan-2-one (2.2 g, 8.3 mmol) and the resulting mixture was heated to reflux for 30 min. After cooling, the solution was added to [4-(6-formyl-pyridin-3-yloxy)-phenyl]-carbamicacid t-butyl ester (2.3 g, 7.4 mmol) in ammonium hydroxide (30%, 23 mL). The reaction mixture was stirred at RT for 5 h, concentrated in vacuo and purified via chromatography to give {4-[3-(4-trifluoromethyl-1H-imidazol-2-yl)-phenoxy]-phenyl}-carbamic acid t-butyl ester (2.1 g, 67% yield). MS (ESI) m/z: (M+H+) 421.1.

Provenance & Evidence