Hydrochloric Acid → HCID 67414100, compound

Participants

Reaction Steps

N-(2,5-Difluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-phenylcyclopropane-1,1-dicarboxamide was dissolved in acetonitrile (5 ml) and 4M HCl in dioxane (0.068 ml, 0.274 mmol) was added slowly with stirring. The mixture was stirred for 1.5 hours at RT as a white solid slowly precipitated from the solution. The salt was collected via suction filtration and washed with diethyl ether. A suspension of the product in a 4:1 mix of acetonitrile and water was lyophilized overnight to obtain N-(2,5-difluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-phenylcyclopropane-1,1-dicarboxamide hydrochloride as a white powder (0.047 g, 65% yield). 1H NMR (400 MHz, DMSO-d6): δ 11.18 (s, 1H), 9.64 (s, 1H), 8.43 (m, 2H), 8.13 (m, 2H), 7.60 (m, 1H), 7.51 (m, 3H), 7.28 (m, 2H), 7.05 (m, 1H), 6.97 (broad s, 1H), 3.84 (s, 3H), 1.63 (m, 2H), 1.53 (m, 2H); MS (ESI) m/z: 490.2 (M+H+).

Provenance & Evidence