Methanesulfonic Acid → HCID 86641695, compound

Participants

Reaction Steps

N-(2-fluoro-5-methyl-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (0.067 g, 0.133 mmol) was dissolved in CH2Cl2 (1 ml), 1.0 M methanesulfonic acid (0.133 ml, 0.133 mmol) was added and the reaction mixture was stirred at RT for 1 hour. The solid was filtered to obtain N-(2-fluoro-5-methyl-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide methanesulfonate salt (55 mg, 67% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.8 (brs, 1H), 9.81 (s, 1H), 8.53 (m, 2H), 8.18 (m, 1H), 8.01 (m, 1H), 7.57 (m, 3H), 7.32 (m, 1H), 7.16 (m, 2H), 6.94 (m, 1H), 3.90 (s, 3H), 2.29 (s, 3H), 2.09 (s, 3H), 1.5-1.7 (m, 4H).

Provenance & Evidence