Hydrochloric Acid → HCID 42603213, compound

Participants

Reaction Steps

To a solution of methyl 4-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]-3-(methyloxy)benzoate (Example 17) (0.1 g, 0.2 mmol) in THF was added a 1M solution of DIBAL-H in THF (800 μL, 4 eq) and the reaction was stirred to room temperature for 2 hours. Solid NH4Cl was added followed by water and a 1N HCl solution. The aqueous phase was extracted with ether and AcOEt, dried over sodium sulphate and evaporated. After recrystallisation from acetonitrile, the title compound was obtained as a white solid (30 mg, 35%). HRMS calculated for C19H18Cl2N4O3 (M+H)+421.0834, found: 421.0834, Rt: 2.94 min. MP: 136° C.

Provenance & Evidence