Water → HCID 42603285, compound

Participants

Reaction Steps

To a solution of 1-[(3,4-dichlorophenyl)methyl]-N-[3-(hydroxymethyl)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide (Example 24) (0.1 g, 0.25 mmol) in a mixture of DCM/THF were added NEt3 (75 μL, 2 eq) and acetyl chloride (25 μL, 1.2 eq). The reaction was stirred at room temperature for 2 hours. Water was added and the product was extracted with ether, dried over sodium sulphate and evaporated in vacuo. The title compound was obtained as a white solid after recrystallisation from isopropyl ether (a couple drops of DCM) (60 mg, 54.5%). HRMS calculated for C20H18Cl2N4O3 (M+H)+ 433.0834, found: 433.0812, Rt: 3.14 min. MP: >70° C. (sticky).

Provenance & Evidence