Hydrochloric Acid → HCID 46182084, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-(2-iso-propoxypyridin-3-ylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (2.04 g, 5.7 mmol) was suspended in MeOH (24 mL). Into this solution was added a solution of aqueous 2M sodium hydroxide (6.0 mL, 12 mmol) and the reaction stirred at 60° C. for 1 hour. The solution was cooled in an ice-bath and concentrated hydrochloric acid added until the solution reached pH 5. The precipitate was collected, washed with water and dried to yield off-white solid (1.50 g, 76%).

Provenance & Evidence