Sodium Hydroxide → HCID 46182215, compound

Participants

Reaction Steps

Aqueous NaOH (2M, 0.175 mL) was added into a suspension of methyl 4-(6-(3-methoxypropoxy)-2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (0.034 g, 0.07 mmol) and the reaction mixture stirred at ambient temperature for 18 hours. The solution was adjusted to pH 2 using 10% aqueous KHSO4 and the resultant suspension was filtered. The solid was washed with water, diethyl ether and dried in vacuo over P2O5 to afford off-white solid (0.024 g, 73%).

Provenance & Evidence