2-Methoxyethanol → HCID 46182216, compound

HRID 450572Notes

Reaction equation

COC[CH2:4][CH2:5][O:6][C:7]1[N:12]=[C:11]([O:13][CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:10]([NH:20][C:21]2[C:22]3[C:29]([CH3:30])=[C:28]([C:31]([OH:33])=[O:32])[S:27][C:23]=3[N:24]=[CH:25][N:26]=2)=[CH:9][CH:8]=1.[CH3:34][O:35]CCO>>[CH3:34][O:35][CH2:4][CH2:5][O:6][C:7]1[N:12]=[C:11]([O:13][CH:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:10]([NH:20][C:21]2[C:22]3[C:29]([CH3:30])=[C:28]([C:31]([OH:33])=[O:32])[S:27][C:23]=3[N:24]=[CH:25][N:26]=2)=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 80192-Methoxyethanol

HCID 46182215HCID 46182215, compound

Product 1

HCID 46182216HCID 46182216, compound

Procedure

Prepared as described for 4-(6-(3-methoxypropoxy)-2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid except that 2-methoxyethanol was used in place of 3-methoxypropan-1-ol in the first step.

Workup

customPrepared

Sources & evidence

ORD record: ord-cca2fede8f93462987edf1dd41b216eb
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08486953B2

Reaction notes

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