Hydrochloric Acid → HCID 46182256, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (0.05 g, 1.2 mmol) in water (1.0 mL) was added into a stirred suspension of methyl 4-(4-fluoro-2-(piperidin-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (0.10 g, 0.2 mmol) in THF (3 mL) and the reaction stirred at ambient temperature overnight. The solution was cooled in an ice-bath and 2N hydrochloric acid added until the solution reached pH 5. The precipitate was collected, washed with water and dried over P2O5 to yield colourless solid (0.056 g, 58%).

Provenance & Evidence