Ammonia → HCID 67026303, compound

HRID 450605Notes

Reaction equation

HRID 450605 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:13]=1[C:14](O)=O.N>>[F:11][C:12]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:13]=1[C:14]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[N:10]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 763392,5-Difluorobenzoic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 67026303HCID 67026303, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,5-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.41-7.56 (m, 2 H), 7.65 (ddd, J=7.9, 5.0, 1.0 Hz, 1 H), 7.98-8.04 (m, 1 H), 8.57 (dt, J=8.0, 1.9 Hz, 1 H), 8.75 (dd, J=5.2, 1.6 Hz, 1 H), 9.31 (dd, J=2.0, 0.8 Hz, 1 H); MS (DCI/NH3) m/z 260 (M+H)+.

Sources & evidence

ORD record
ord-d69db77b67204c6aa462054133af310b
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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