Ammonia → 3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	3-Pyridinecarbonyl chloride, hydrochloride (1:1)	HCID 88438	—
Reactant	2,3-difluoro-N'-hydroxybenzenecarboximidamide	HCID 3278378	—
Product	3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole	HCID 67026030	—

Reaction Steps

The title compound was prepared according to the procedure of Example 1 using 2,3-difluoro-N′-hydroxybenzimidamide (Tyger Scientific) and nicotinoyl chloride hydrochloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.42-7.61 (m, 1 H), 7.67-7.85 (m, 2 H), 7.91-8.04 (m, 1 H), 8.57 (dt, J=8.1, 1.9 Hz, 1 H), 8.92 (dd, J=4.8, 1.6 Hz, 1 H), 9.36 (dd, J=2.4, 0.8 Hz, 1 H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08486979B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-7975f04eba414c908c32fc0a3e5fa393
Source note	uspto-grants-2013_07