HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-Chloro-3-fluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Reactant | 4-Chloro-3-fluorobenzoic acid | HCID 2736536 | — |
| Product | 5-(4-Chloro-3-fluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026005 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 4-chloro-3-fluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.64 (ddd, J=7.9, 5.0, 1.0 Hz, 1 H), 7.78 (dd, J=8.3, 7.5 Hz, 1 H), 8.07 (ddd, J=8.3, 2.0, 0.8 Hz, 1 H), 8.12 (dd, J=9.5, 2.0 Hz, 1 H), 8.55 (dt, J=7.9, 2.0 Hz, 1 H), 8.74 (dd, J=5.0, 1.8 Hz, 1 H), 9.28-9.30 (m, 1 H) ppm; MS (DCI/NH3) m/z 276 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486979B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-408ef45dd7c140039c3b342232301342 |
| Source note | uspto-grants-2013_07 |