3-(3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile → HCID 67026083, compound

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Reaction Steps

A solution of the product of Example 1 (248 mg, 1 mmol) in THF (10 ml) was stirred with potassium trimethylsilanolate (257 mg, 2.000 mmol) at 65° C. for 10 hours. It was then quenched with water (20 mL) and stirred at ambient temperature for 2 hours. The precipitate was filtered and dried under vacuum to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 7.67 (ddd, J=7.9, 4.8, 0.8 Hz, 1 H), 7.78 (t, J=7.7 Hz, 1 H), 8.23 (dt, J=8.1, 1.4, 1.2 Hz, 1 H), 8.30 [s (broad, 2H], 8.36 (dt, J=8.1, 1.3 Hz, 1 H), 8.48 (dt, J=7.9, 2.0 Hz, 1 H), 8.68-8.73 (m, 1 H), 8.83 (dd, J=4.8, 1.6 Hz, 1 H), 9.28 (dd, J=2.2, 1.0 Hz, 1 H) ppm; MS (DCI/NH3) m/z 267 (M+H)+.

Provenance & Evidence