HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-(2-Fluoropyridin-3-yl)-1,2,4-oxadiazol-3-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Fluoropyridine-3-carbonyl chloride | HCID 21959582 | — |
| Reactant | 3-Cyano-N-hydroxy-benzamidine | HCID 57368933 | — |
| Product | 3-(5-(2-Fluoropyridin-3-yl)-1,2,4-oxadiazol-3-yl)benzonitrile | HCID 67025999 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 4B using 3-cyano-N′-hydroxybenzimidamide (Example 4A) and 2-fluoronicotinoyl chloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.87 (m, 1 H), 7.95 (m, 1 H), 8.17 (m, 1 H), 8.17 (m, 1 H), 8.43 (m, 1 H), 8.6 (m, 1 H), 8.8 (m, 1 H) ppm; MS (DCI/NH3) m/z 267 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486979B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-e9554b041b4048bba8a50edec840f13f |
| Source note | uspto-grants-2013_07 |