HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| Reactant | N-Hydroxy-4-pyridazinecarboximidamide | HCID 136140373 | — |
| Product | 5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole | HCID 44511305 | — |
Reaction Steps
The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 3,4-difluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.80 (dt, J=10.5, 8.3 Hz, 1 H), 8.08-8.19 (m, 1 H), 8.29 (dd, J=5.4, 2.4 Hz, 1 H), 8.31-8.38 (m, 1 H), 9.55 (dd, J=5.4, 1.4 Hz, 1 H), 9.82 (dd, J=2.2, 1.2 Hz, 1 H) ppm; MS (DCI/NH3) m/z 261 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486979B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-8bb930946e53406a98bb7b8ad02c7cef |
| Source note | uspto-grants-2013_07 |