HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3-Fluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| Reactant | N-Hydroxy-4-pyridazinecarboximidamide | HCID 136140373 | — |
| Product | 5-(3-Fluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole | HCID 44544671 | — |
Reaction Steps
The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 3-fluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.45-7.53 (m, 1 H), 7.69 (td, J=8.1, 5.6 Hz, 1 H), 8.00 (ddd, J=9.1, 2.6, 1.4 Hz, 1 H), 8.11 (dt, J=7.9, 1.2 Hz, 1 H), 8.39 (dd, J=5.4, 2.2 Hz, 1 H), 9.45 (dd, J=5.2, 1.2 Hz, 1 H), 9.87 (dd, J=2.2, 1.4 Hz, 1 H) ppm; MS (DCI/NH3) m/z=243 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486979B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1a9abda82418430bb737a3f5d901304d |
| Source note | uspto-grants-2013_07 |