HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(Pyridazin-4-yl)-5-(2,3,4-trifluorophenyl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,3,4-Trifluorobenzoyl chloride | HCID 2734022 | — |
| Reactant | N-Hydroxy-4-pyridazinecarboximidamide | HCID 136140373 | — |
| Product | 3-(Pyridazin-4-yl)-5-(2,3,4-trifluorophenyl)-1,2,4-oxadiazole | HCID 44544773 | — |
Reaction Steps
The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 2,3,4-trifluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.40-7.50 (m, J=9.3, 9.3, 7.0, 2.2 Hz, 1 H), 8.10-8.20 (m, 1 H), 8.39 (dd, J=5.4, 2.4 Hz, 1 H), 9.46 (dd, J=5.3, 1.2 Hz, 1 H), 9.87 (dd, J=2.2, 1.2 Hz, 1 H) ppm; MS (DCI/NH3) m/z=279 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486979B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-bc0e7bb9e8604021b4b12e0edd31f82a |
| Source note | uspto-grants-2013_07 |