p-Toluenesulfonic acid monohydrate → HCID 86624306, compound

Participants

Reaction Steps

A solution of the product of Example 101A (52 mg, 0.2 mmol) in ethyl acetate (5 mL) was stirred with a solution of p-toluenesulfonic acid monohydrate (Aldrich, 46.0 mg, 0.24 mmol) in ethyl acetate (1.0 mL) at ambient temperature for 10 hours. The precipitates were collected by filtration and dried to give the title compound. 1H NMR (300 MHz, CDCl3) δ 2.40 (s, 3 H), 7.25 (d, J=8.2 Hz, 2 H), 7.36-7.53 (m, 1 H), 7.83 (d, J=8.3 Hz, 2 H), 8.03-8.12 (m, 2 H), 9.57 (s, 1 H), 9.71 (s, 2 H); MS (DCI/NH3) m/z 261 (M+H)+.

Provenance & Evidence