Ammonia → HCID 44544872, compound

HRID 450678Notes

Reaction equation

HRID 450678 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([OH:13])=O)=[CH:7][C:5]=2[CH:6]=1.O[N:15]=[C:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1.N>>[CH3:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]3[O:13][N:23]=[C:16]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[N:15]=3)=[CH:7][C:5]=2[CH:6]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 10921182-methyl-1-benzofuran-5-carboxylic acid

Product 1

HCID 44544872HCID 44544872, compound

Procedure

The title compound was prepared according to Method C using 2-methylbenzofuran-5-carboxylic acid (Chembridge) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 3.33 (s, 3 H), 6.58-6.97 (m, 1 H), 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1 H), 7.78 (d, J=8.5 Hz, 1 H), 8.40-8.55 (m, 2 H), 8.82 (dd, J=4.7, 1.7 Hz, 1 H), 9.27 (dd, J=2.2, 0.8 Hz, 1 H) ppm; MS (DCI/NH3) m/z 278 (M+H)+.

Sources & evidence

ORD record
ord-c002ecf9c8db4ff8867d3b94d2e385df
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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