Ammonia → HCID 44545181, compound

HRID 450696Notes

Reaction equation

HRID 450696 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=O)=[CH:10][C:4]=2[O:3]1.O[N:15]=[C:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1.N>>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:16]2[N:23]=[C:11]([C:9]3[CH:8]=[CH:7][C:5]4[NH:6][C:2](=[O:1])[O:3][C:4]=4[CH:10]=3)[O:13][N:15]=2)[CH:18]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 3914722-Oxo-2,3-dihydro-1,3-benzoxazole-6-carboxylic acid

Product 1

HCID 44545181HCID 44545181, compound

Procedure

The title compound was prepared according to Method C using 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid (Eur. J. Med. Chem. 1974, 9, 491-6.) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 7.35 (d, J=8.7 Hz, 1 H), 7.65 (dd, J=7.5, 4.4 Hz, 1 H), 8.04 (d, J=1.6 Hz, 1 H), 8.07 (s, 1 H), 8.44 (dt, J=7.9, 2.0 Hz, 1 H), 8.82 (dd, J=4.8, 1.6 Hz, 1 H), 9.25 (d, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 281 (M+H)+.

Sources & evidence

ORD record
ord-dd19f4abc098452f8c6fd795e03e68e7
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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