4-(Propan-2-yl)benzene-1-sulfonyl chloride → HCID 67023981, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(6-amino-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-propionamide (290 mg, 1.26 mmol) in pyridine (10 ml) at 0° C. 4-isopropyl-benzenesulfonyl chloride (280 mg, 1.26 mmol) was added. The mixture was stirred at 0° C. for 1 h and 16 h at room temperature. After evaporation under reduced pressure the obtained residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The organic layer was washed twice with saturated aqueous NaHCO3, dried over MgSO4, filtered and the solvent evaporated under reduced pressure to give the product as a brown resin (530 mg, 100%).

Provenance & Evidence