反应详情

温度

55 °C

A mixture of methanesulfonic acid indan-2-yl ester (18.65 g, 87.9 mmol) and tetraethylammonium cyanide (15.10 g) in acetonitrile (180 mL) was heated to 55° C. for 5 hours, cooled and concentrated. The residue was partitioned between ethyl acetate and water, and the organic phase separated. This was dried over MgSO4 and the filtered solution was concentrated and then separated by column chromatography (dichloromethane:ethyl acetate, 6:1-1:1) to give the product as a red solid (6.51 g, 52%).

1. temperaturecooled
2. concentrationconcentrated
3. customThe residue was partitioned between ethyl acetate and water
4. customthe organic phase separated
5. dry with materialThis was dried over MgSO4
6. concentrationthe filtered solution was concentrated
7. customseparated by column chromatography (dichloromethane:ethyl acetate, 6:1-1:1)