HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 450755Generated: October 25, 2026
Dimethyl Sulfoxide → 2-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione
https://huagongshe.com/reaction/450755
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Chloromethyl)-4-methanesulfonylbenzene | HCID 123530 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione | HCID 59479269 | 64.2% |
Reaction Steps
To a mixture of 659 mg of 1-(chloromethyl)-4-(methylsulfonyl)benzene and 10 ml of DMSO were added 525 mg of N-hydroxyphthalimide and 445 mg of potassium carbonate, followed by stirring at 50° C. for 2 hours. The reaction solution was cooled, water was then added thereto, and the precipitated crystal was collected by filtration to obtain 685 mg of 2-{[4-(methylsulfonyl)benzyl]oxy}-1H-isoindole-1,3(2H)-dione as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08486970B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-3b50be10981d4f3082d19f516d862428 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
